Abstract:5G network provides a communication platform for the information interaction between switch protection devices of distribution network. In order to solve the risk of leapfrogging caused by the setting mismatch of traditional overcurrent protection setting value of distribution network, a regional protection scheme for distribution network is proposed based on 5G communication, and through the actual application carried out in Chengdu distribution network, the feasibility of the proposed scheme is verified. Firstly, the architecture of 5G regional protection in distribution network is given. Secondly, the action logic of 5G regional protection in distribution network is analyzed, and the fault is located based on the combined signals of overcurrent and direction signs of the switches in the area. Finally, the setting calculation principle of 5G regional protection in distribution network is given.