Network reconfiguration is widely applied in power gird for service restoration, renewables penetration promotion and power loss reduction. In order to realize the economic operation of region power grid, the daily active power losses of region power grid under two different operation modes are calculated. Under different loading conditions, the active power losses of region power grid under different operation modes are calculated, which provides a foundation for the consolidation of regional power grid in long-term operation. Finally, the monthly loss reduction of regional power grid is calculated after the operation mode is solidified, that is, after the network reconfiguration. It is verified that under the demands of safety operation and reliability of power supply, the long-term economic operation of regional power grid can be realized through network reconfiguration.